EndoArt®:
The future of corneal treatment
EndoArt® corneal artificial endothelial layer, is the first synthetic implant to treat corneal edema, saving vision and restoring function by creating a new type of corneal availability. EndoArt® attaches to the back of the corneal surface, preventing the transfer of fluids into the cornea and inhibiting the buildup of fluid that we know as edema. Performed via small incisions, the procedure is minimally invasive, preventing further injury to fragile eye tissue and encouraging a high degree of implantation success.
EndoArt® has demonstrated a substantial decrease in edema, improvement in vision, and reduction in pain in clinical studies, and it is CE- approved as well as in Israel (AMAR).
The Need
The human ocular endothelium can never regenerate. Therefore, any damage to the endothelium, including aging, results in corneal edema: a swelling of the eye’s clear, dome-shaped outer surface. This affects millions of people around the world. Corneal edema causes pain and cloudy vision. If left untreated it can permanently damage the eye and affect sight. Current treatments for corneal edema depend on donated tissue. These transplants are often successful, but they are available only to those with access to human corneas. Meanwhile 13 million others experience first-hand the great shortage of donated corneas. They wait for human corneal transplants, in pain and with impaired vision, without an alternative solution.
EndoArt® is a game-changer
EndoArt® creates a new type of corneal availability.
100% synthetic
Made from synthetic materials, EndoArt® introduces an effective corneal edema treatment that is globally available and immediately ready to use.
Biocompatible sterile material
EndoArt’s minimally invasive application is well tolerated because it is made of sterile biocompatible material that is inherent to human tissue and cannot be rejected.
Scalable manufacturing
EndoArt® can be manufactured in large quantities, plus future design development can even include refractive correction.
Mechanism of action
Step 1
EndoArt® applies via a minimally invasive procedure.
Step 2
It attaches to the posterior part of the cornea.
Step 3
EndoArt® creates a passive barrier to fluids, allowing nutrition exchange on the periphery.
Step 4
Fluid balance reverts to a normal level and the cornea clears.
Clinical studies
Artificial Endothelial Layer Implantation After Multiple Failed Keratoplasties
The purpose of this study: Presenting the first case of noncellular corneal endothelial substitute after multiple failed penetrating keratoplasty and lamellar
endothelial keratoplasty.
Early Outcomes of an Artificial Endothelial Replacement Membrane Implantation After Failed Repeat Endothelial Keratoplasty
The purpose of this study was to report the outcomes of a novel artificial endothelial replacement membrane implant for treating corneal edema after failed repeat endothelial keratoplasty (EK).
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Prof. Gerd U. Auffarth, Heidelberg MC, Germany
The EndoArt could provide a paradigm shift in the treatment of patients with endothelial failure while eliminating the need for human donor tissue.
Dr. Naftali Modi, Rambam MC, Israel
My experience shows that it is an extremely easy procedure, especially compared to DSAEK or DMEK.
Prof. Merab Dvali
Tbilisi State Medical University, Georgia
I’m grateful…to take first steps towards eliminating the global shortage of corneal tissue
Dr Sunita Chaurasia
LV Prasad Eye Institute Hyderabad, India
The introduction of EndoArt, which serves as an artificial layer reducing the fluid transfer from the aqueous to the corneal stroma, is a huge step forward.
