Therapeutic Hyper-CL soft contact lens in Sjögren’s syndrome
September 2022American Journal of Ophthalmology Case Reports, Volume 28, December 2022, 101685
Vito Romano, Davide Romanoa, Paolo Semeraro, Eliana Forbice, Antonio Iaria, Teodoro Pizzolante, Micol Frassi, Franco Franceschini, Francesco Semeraro
Abstract
Purpose
To report increased corneal bioavailability of allogenic serum when combined with Therapeutic Hyper-CL™ soft contact lens in a patient with severe Sjogren’s syndrome-associated dry eye.
Observations
A 57-year-old woman with a medical history of bilateral severe Sjögren’s syndrome-associated dry eye and previous amniotic membrane patch for autoimmune corneal perforation in her left eye was referred for left eye recurrence of progressive melting and pending perforation. After manual corneal trephination, full thickness transplant and sutured amniotic membrane patch, a Therapeutic Hyper-CL™ soft contact lens (EyeYon Medical, Ness Tziona, Israel) was fit. The patient was commenced in the left eye with topical corticosteroid, antibiotic, and allogenic serum eye drops. In the right eye the patient had silicone hydrogel bandage contact lens and was under same treatment of the left eye for previous endothelial keratoplasty. In order to evaluate the efficacy and increased corneal availability of drugs provided by Therapeutic Hyper-CL™ compared with silicone hydrogel soft contact lens, anterior segment OCT was performed.
Conclusions and importance
The anterior segment OCT showed a thicker meniscus of fluid and possibly subsequent increase of trophic factors bioavailability in left eye compared with right eye. Therefore, in case of severe and refractory dry-eye disease the combination of Therapeutic Hyper-CL™ and serum eye drops may be representing a valid therapeutic approach.